Hubrecht Institute, NL. Dive into the research topics where Jop Kind is active. We profiled these genome-lamina interactions in single cells to obtain better understanding in gene-regulation control in pre- and post-implantation embryos (Borsos et al., 2019, Nature) (Figure 2). 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. 3 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. His group is focused on understanding how spatial and temporal changes in genome architecture affect gene expression. To achieve this, we make use of organoid and mouse models that capture tumorigenesis all the way from the initiating stages towards metastasis. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute. PMID: 31118510 PMCID: PMC6546605 Read more | 11 November . Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis. Go to Website Navigation: Home; about narcis; login; Nederlands; contact. Susanne Lens Group. 3584 CT Utrecht Wednesday 22 July. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. 12:35. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute . 12:35. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. Jop, now Group Leader at … … 3 day event 20 - 22 Jan. Masterclass: Artificial intelligence and deep learning in basic research and clinical practice in Oncology: In-depth sessions. Hubrecht Institute, NL. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on … Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Online event. Jop Kind is group leader at the Hubrecht Institute and Oncode Investigator. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Together with her group, Knipscheer studies the repair pathways that cells use to correct ICLs. “That allows us to make a family tree of the various epigenetic stages that preceded the choice the cell eventually made. Follow. j.kind@hubrecht.eu. She and others previously discovered that the Fanconi anemia (FA) pathway plays a crucial role in repairing ICLs. See what employees say about what it's like to work at Hubrecht Institute. 23. He will zoom in on single-cell epigenomics and multi-omics. Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Hubrecht Institute opens new laboratory building. Research output per year. Miao-Ping Chien. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Jop Kind, Junior Group Leader at the Hubrecht Institute. In addition, scDam&T allows determining cellular identity of cells in complex tissues -such as embryos or tumors- based on transcriptomics, in direct relation to their epigenetic regulatory landscapes (DamID). Hubrecht Institute, Developmental Biology and Stem Cell Research | 6,134 followers on LinkedIn. Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. jop kind Hubrecht Institute Verified email at hubrecht.eu. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research . Geert Kops Group. 23. The John Kendrew Young Scientist Award (JKA) was launched in 2007 as an initiative from the EMBL Pensioner’s Association to honour EMBL’s first Director General, Sir John Kendrew (1975-1982), and to support scientists in the early stages of their career. Jop Kind. Institute of Molecular Biotechnology, Austrian academy of science. Furthermore, as we consider technology development a core business of the group, we are continuously exploring ways to obtain richer single-cell datasets. Kim L de Luca 1 , Jop Kind 2 Affiliations 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. 3,331. (Jop) Kind: Active at: The Netherlands Cancer Institute: Hubrecht Institute for Developmental Biology and Stem Cell Research: Email address: If you have any questions or problems regarding login, please contact narcis@dans.knaw.nl. Read the new partnership agreement between Pontiac School District and the state including exhibits of data on the schools achievement gaps. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The Netherlands; s.lochs@hubrecht.eu (S.J.A.L. The Kind group researches gene regulation – how genes are turned on or off – and the influence of the packing of DNA, the epigenetics, on this mechanism. The European Research Council (ERC) awards grants to individual scientists of all nationalities and ages who perform groundbreaking research. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowl … 13:35. * Correspondence: j.kind@hubrecht.eu † These authors contributed equally to this work. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Their combined citations are counted only for the first article. Reads . Kind’s group previously developed advanced techniques with which they can study epigenetics in a single cell and match it with the cell’s choice of identity. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. Jop Kind Group Jop Kind Oncode Investigator at Hubrecht Institute My Research. The group focuses on a specific type of DNA damage called a DNA interstrand crosslink (ICL). 3584 CT Utrecht In particular, the group is interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in living cells. cells Review Lamina Associated Domains and Gene Regulation in Development and Cancer Silke J. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Save the date! The grant was awarded to only 327 out of 2506 applicants. Jop is currently an associate professor at the Hubrecht Institute in Utrecht where his lab continues to develop new techniques to single-cell profile gene-regulation to obtain better insights into the mechanisms that govern cell fate choice in development and disease. Hubrecht Institute. Tumorigenesis involves the continuous selective adaptation of cells from healthy tissue, to adenoma, carcinoma and eventually metastasis. Additionally, they study how new cell types arise in the early development of mouse embryos, in which epigenetics plays an important role. The grant allows her to expand her group with 4 researchers for the duration of 5 years. Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. That knowledge underlines the link between alcohol consumption and cancer. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Save the date for our Annual Conference! Cited by. martin 1st April 2015 News Read more Hiding in plain sight Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. j.kind@hubrecht.eu. Annual Scientific Meeting. Erasmus University Medical Center/ UFO Biosciences, NL . Jop Kind is group leader at the Hubrecht Institute and Oncode investigator. 13:05. PHOTO: EMBL . Hubrecht Institute, NL. Hubrecht Institute launches new website! Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. To obtain detailed insight into this trajectory, it is essential to capture all the stages with single-cell accuracy. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Biography. The researchers are each given two million euros to strengthen their research groups and continue their innovative research in the next 5 years. Oncode Investigator at Hubrecht Institute My Research Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Tumor-cell trajectories in organoid and mouse models About. Credit: Jop Kind, copyright Hubrecht Institute. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. Jop Kind. These topic labels come from the works of this person. An important contributor to the regulation of gene expression is the spatial positioning of genes within the 3-dimensional space of the nucleus. Knipscheer’s group will use the ERC grant to further research this pathway. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. We have developed scDam&T, a method to simultaneously capture protein-DNA interactions and transcriptomes in the same cell (Rooijers et al, 2019, Nature Biotechnology) (Figure 1). Since October 2014 he is Junior Group Leader at the Hubrecht Institute. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. jop kind. Wouter de Laat Group. Electronic address: j.kind@hubrecht.eu. Nicolas Rivron. The Consolidator Grant is specifically awarded to researchers who have formed their own research group relatively recently and aim to further strengthen it further. Maria-Elena Torres-Padilla is group leader and director of the Institute of Epigenetics and Stem Cells (IES), Helmholtz Center Munich and professor of Stem cell biology at the Ludwig-Maximilians University. Hubrecht Institute. Salaries, reviews, and more - all posted by employees working at Hubrecht Institute. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Overview; Fingerprint; Network; Research Output (8) Similar Profiles (28) If you made any changes in Pure these will be visible here soon. Jop Kind. The research group of Knipscheer researches DNA repair: how does our genetic material remain stable and how do we prevent the development of genetic diseases such as cancer? Jop, now Group Leader at … Hubrecht Institute Summary: ... but instead attached to the ceiling at anchor points," says Jop Kind, group leader at the Hubrecht Institute. 2 day event 19 - 20 Apr. Jop Kind, group leader at the Hubrecht Institute, has been awarded the John Kendrew award. Read more | 18 November . The institute encompasses 23 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues and organisms. 800,000 euros or read online for Free `` Cited by '' count includes citations to the articles... Consumption and cancer Knipscheer is group Leader at the Hubrecht Institute and investigator! 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